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DSS Crosslinker
CAS No. 68528-80-3
DSS Crosslinker( —— )
Catalog No. M22922 CAS No. 68528-80-3
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm that are used to conjugate proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 37 | In Stock |
|
| 500MG | 51 | In Stock |
|
| 1G | 67 | In Stock |
|
Biological Information
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Product NameDSS Crosslinker
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NoteResearch use only, not for human use.
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Brief DescriptionDSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm that are used to conjugate proteins.
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DescriptionDSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm that are used to conjugate proteins. DSS crosslinker can be used to conjugate or crosslink intracellular proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayAntibody Drug Conjugates (ADC)
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TargetADCs Linker/Click Chemistry
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RecptorNon-cleavable
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Research Area——
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Indication——
Chemical Information
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CAS Number68528-80-3
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Formula Weight368.34
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Molecular FormulaC16H20N2O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (678.72 mM)
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SMILESO=C(ON1C(CCC1=O)=O)CCCCCCC(ON2C(CCC2=O)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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